Losartan Carboxylic Acid
CAS No. 124750-92-1
Losartan Carboxylic Acid ( EXP-3174; EXP 3174;Losartan Carboxylic Acid )
产品货号. M17904 CAS No. 124750-92-1
EXP-3174 is a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥348 | 有现货 |
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10MG | ¥583 | 有现货 |
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25MG | ¥1191 | 有现货 |
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50MG | ¥2130 | 有现货 |
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100MG | ¥3183 | 有现货 |
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200MG | ¥4666 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Losartan Carboxylic Acid
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述EXP-3174 is a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation.
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产品描述EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP-3174 is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.
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同义词EXP-3174; EXP 3174;Losartan Carboxylic Acid
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通路Others
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靶点Other Targets
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受体AT1 receptor
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研究领域——
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适应症——
化学信息
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CAS Number124750-92-1
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分子量436.9
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分子式C22H21ClN6O2
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纯度98%
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溶解度——
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SMILESc1(n(c(c(n1)Cl)C(=O)O)Cc1ccc(cc1)c1c(cccc1)c1n[nH]nn1)CCCC
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化学全称1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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